Discovering the Science Behind Q10 Absorption. In the field of health and well-being, understanding the mechanism of Q10 absorption is essential for unlocking its remarkable benefits. Join us on a journey through the complex world of Q10 absorption mechanism, highlighting the critical role of water-soluble Q10. Let’s uncover the mysteries within our intestines and uncover strategies to optimize Q10 absorption.


The Power of Efficient Q10 Absorption

The true magic of Q10 lies in its absorption. Q10’s potential benefits come to life when it’s absorbed effectively, contributing to:

Q10 structure
Q10 structure

Aging and Q10: The Natural Clock

As we age our body’s natural Q10 production diminishes, underscoring the need to supplement to maintain optimal levels. However, a challenge arises—Q10 is not easily absorbed.

Organ content of total CoQ10 decreases with age (Littarru G., Lambrechts P. 2011)
Organ content of total CoQ10 decreases with age (Littarru G., Lambrechts P. 2011)

Understanding the Q10 Absorption Mechanism

Understanding the absorption of lipophilic nutrients, such as Q10, involves crucial steps:

  1. Mixed Micelles Formation: Q10’s journey begins with the creation of “mixed micelles” alongside components of fatty meals. Bile and pancreatic secretions facilitate this process within the small intestine.
  2. Uptake into Intestinal Cells: Q10’s absorption efficiency is related to its dose and follows a diffusion process. The precise manner by which lipophilic molecules traverse cell membranes within enterocytes is still under ongoing research.
  3. Incorporation into Chylomicrons: Q10 becomes a part of chylomicrons, which are then secreted into the lymphatic system. These chylomicrons serve as delivery agents to the liver and further to target tissues via LDL transportation.
Absorption mechanism of lipophilic nutrients and Q10
Absorption mechanism of lipophilic nutrients and Q10

The Challenge of Lipophilic Nutrients

Q10 poses a unique challenge due to its lipophilic nature. Its absorption journey involves passing through the “Unstirred Water Layer” (UWL) in our small intestines. While shorter-chain fatty acids easily cross this barrier, Q10’s higher lipophilicity demands assistance from bile acids to facilitate micellation.

Enhancing Absorption with Water Solubility

The challenge arises from Q10’s long chain and poor water solubility, leading to limited absorption rates. Regular Q10 powder absorption is around 3-5%. A solution arises by enhancing water solubility, aiding bile acids in their role and contributing to improved Q10 absorption.

Unveiling the Promise of Water-Soluble Q10

Published research supports the concept that optimal Q10 absorption benefits from a dilution effect. Distributing Q10 evenly across the epithelium improves absorption rates. Dividing Q10 doses yields higher serum levels compared to single doses. Additionally, Q10-enriched olive oil boasts 2-3 times higher absorption than oil-based soft gels. We know that consuming Q10 supplements with meals also enhances their absorption potential.

Watersoluble Q10: A Paradigm Shift

Research demonstrates that watersoluble Q10 exhibits a higher AUC (Area Under the Curve) compared to Q10 powder dissolved in oil-based soft gels. Super micellized Q10 fastly passes the Unstirred Water Layer, enabling rapid and efficient absorption.

Lipophilic nutraceuticals crossing the UWL (Unstirred Water Layer) barrier in our small intestines
Lipophilic nutraceuticals crossing the UWL (Unstirred Water Layer) barrier in our small intestines
Super micellized Q10 passes the Unstirred Water Layer rapidly. This is the basis for a high absorption.
Super micellized Q10 passes the Unstirred Water Layer rapidly. This is the basis for a high absorption.

Pioneering Insights

Leading nutraceutical expert Mr. Raj Chopra highlighted the significance of Q10 absorption over two decades ago. His company, Tishcon Corporation, pioneered hydrosoluble, bioavailability-enhanced Q10 oral finished dosage forms.

Mean plasma coenzyme Q10 values following supplementation (Chopra 1998)
Mean plasma coenzyme Q10 values following supplementation (Chopra 1998)

Groundbreaking Research Achievements 

Professor Miles, a prominent figure from the University of Cincinnati Medical Center, achieved a groundbreaking milestone in the study of Q10 absorption. His research team reported the highest plasma coenzyme Q10 concentration ever documented in existing literature—an impressive 10.7 µmol Q10/L. This extraordinary finding was accomplished using a revolutionary liquid watersoluble Q10-ubiquinol formulation (Miles 2006).

Validating Enhanced Bioavailability

A recent study conducted by Professor Pravst in Slovenia provided further validation of the benefits of water-soluble Q10. The study revealed that the bioavailability of watersoluble Q10 surpasses crystalline Q10 by an impressive 2.4-fold. Intriguingly, while the bioavailability of ubiquinol soft capsules did not exhibit a significant increase, the watersoluble Q10 showcased remarkable enhancements. This single-center, randomized, three-period, crossover intervention study involved a healthy geriatric population receiving a single dose of 100mg of Q10. Comparison between watersoluble Q10, ubiquinol capsules, and generic Q10 capsules demonstrated that even when consumed as Q10, the presence of ubiquinol was prominent in the blood (Pravst 2020).

Japanese Study on Q10 Absorption

A Japanese randomized controlled study delved into the comparison of water-dispersed ubiquinol-Q10 powder and traditional ubiquinol softgels following single oral administration. The study, involving researchers led by a senior Kaneka scientist, yielded compelling results. The solubilized version showcased an astonishingly higher Q10 absorption, nearing a factor of 300% when compared to the conventional softgel capsule. Moreover, the solubilized ubiquinol-Q10 demonstrated effective absorption even under fasting conditions, signifying its versatility (Uchida 2014).

Solubilized ubiquinol-Q10 has 3 times higher absorption vs ubiquinol capsules
Solubilized ubiquinol-Q10 has 3 times higher absorption vs ubiquinol capsules

Quality Assurance Insights

Another recent investigative study conducted in Japan showed a revealing light on the effectiveness of dietary supplements. Japan’s National Consumer Affairs Center (NCAC) conducted rigorous testing on 100 products and arrived at a surprising conclusion. More than 40% of these products did not meet their claimed effectiveness standards. Alarmingly, these products failed to dissolve in water within specified time limits. This raises concerns about the accurate absorption of advertised nutrients from these supplements. These findings shed light on the importance of selecting supplements backed by solid research and quality assurance.

A Future of Enhanced Q10 Absorption

To summarize, taking full benefit of Q10’s full potential required increase bioavailability. Water-soluble Q10 has been shown to have higher Q10 absorption, surpassing conventional oil-based softgels and crystalline powder capsules. This soluble form ensures rapid and reliable absorption, irrespective of dose or timing.

Selecting for bioavailability-enhanced Q10 supplements guarantees superior results.

Certainly, consumers are willing to pay more for bioavailability enhancements.

The evolution of third-generation Q10 products from Japan brings a future of enhanced absorption through natural formulations.