The brain, which is 60-70 percent fat, is very susceptible to oxidative damage, due to its high-fat content. Q10 mental energy science shows that Q10 promotes brain health by protecting brain cells from free radicals and other damaging compounds that have been linked to cognitive decline.
Q10 is cellular energy and defense in one substance.
What does the research say?
Q10 science on Mental Health and Neuroprotection
Coenzyme Q10 conferred a benefit to physical function and symptoms in veterans with Gulf War illness (Golomb 2014).
Serum coenzyme Q10 levels were inversely associated with the risk of disabling dementia (Yamagishi 2014).
A clinical study with 46 heart failure patients showed a significant improvement in the quality of life (QOL) on 6 minutes walk test versus the control group (Adarsh 2008).
8 weeks of Q10 supplementation significantly increased vitality and mental health QOL scores in middle-aged and elderly individuals (Shimizu 2015).
Q10 added to multivitamins/minerals promotes cerebral vasodilation (Kennedy 2016).
The usefulness of regular intake of the reduced form of CoQ10 for stress management for workers (Kawaharada 2013)
The Q10 contents of all regions of the brain are decreased during aging (Söderberg 1990).
Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects (Matthews 1998).
Ubiquinol-Q10 contributes to the improvement of QOL in healthy individuals with mild fatigue by reducing fatigue and sleepiness following cognitive function load, promoting motivated engagement with cognitive function tasks while providing a relaxing effect, and reducing oxidative stress (Mizuno 2020).
Q10 science on Brain Medicine
Efficacy of Q10 (300 mg/day) on migraine was investigated in a double-blind placebo-controlled trial with 42 migraine patients, CoQ10 decreased the frequency of migraine attacks (Sandor 2005).
In patients with low CoQ10 ground level, tinnitus expression significantly decreased after Q10 application (Khan 2007).
Three months of intake of CoQ10 (1-3 mg/kg body weight) by individuals with CoQ10 deficiency reduced migraine frequency from 19 to 12,5 days per month. In more than 46% of these patients, the headache frequency was reduced with 50% or more. Also, disability due to migraine attacks improved remarkably (Hershey 2007).
A 2021 meta analysis concluded that Q10 has beneficial effects in reducing duration and frequency of migraine attack (Sazali 2021).
Q10 is effective for the treatment of bipolar depression (Maryam 2018).
High-dose ubiquinol-Q10 supplementation (up to 1200 mg/day) is tolerable and improves cerebral mitochondrial oxidative metabolism in MSA. Ubiquinol-Q10 passes the blood-brain barrier (BBB) in humans (Mitsui 2017).
Reduced Q10 may significantly improve Parkinson’s disease with wearing off, as judged by total UPDRS scores (Yoritaka 2015).
Evidence on neuroprotective properties of coenzyme Q10 in the treatment of glaucoma (Martucci 2018).
What experts say on Q10 mental energy science
The brain is very susceptible to oxidative damage due to its high fatty acid content and its high demand for oxygen. This oxidative damage enhances the production of harmful compounds that could affect memory, cognition and physical functions. Q10 may reduce these harmful compounds, possibly slowing the progression of Alzheimer’s and Parkinson’s disease.
Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects.