For different organs a decrease of Q10 has been found with age.
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Q10 treatment showed a remarkable improvement in clinical symptoms and headache in fibromyalgia patients (Cordero 2012).
Q10 confers potential therapeutic benefits on fatigue and biochemical parameters in CFS (Castro-Marrero 2015).
A study in Spain among middle-aged adults with fibromyalgia (chronic, wide-spread muscular pain and fatigue) found that 100 mg Q10 taken three times daily for 40 days significantly improved measures of interpersonal sensitivity, depression, anxiety, hostility, and symptoms of somatization and obsessive-compulsion compared to placebo (Alcocer-Gomez 2017).
A meta-analysis shows that 200 – 300 mg Q10 supplementation per day can lower fatigue in statin-associated myopathy and fibromyalgia patients (Mehrabania 2019).
This 2022 systematic review and meta-analysis of randomized controlled trials concludes that CoQ10 is an effective and safe supplement for reducing fatigue symptoms. (Tsai 2022).
Q10 science on Anti-aging
The concentration of coenzyme Q10 in the body decreases year by year, indicating that it has a close relationship with aging (Kalen 1989).
Recent advances in Q10 treatment of human diseases and the slowing down of the aging process (Hernández-Camacho 2018)
Q10 and its role in dietary therapy against aging (Varela-López 2016)
In a Swedish study, elderly individuals (>70 years) who received a combination of selenium and Q10 for four years reported an improvement in vitality, physical performance, and quality of life (Johansson 2015).